The effects of injury on the adaptive immune response.

@article{Lederer1999TheEO,
  title={The effects of injury on the adaptive immune response.},
  author={James A. Lederer and Mary L. Rodrick and John A. Mannick},
  journal={Shock},
  year={1999},
  volume={11 3},
  pages={153-9}
}
For more than thirty years it has been apparent that serious injury in humans and experimental animals is associated with a decrease in immune functions dependent upon T cells, the principal cells involved in initiating adaptive immune responses. This review focuses on more recent evidence that T helper cell function is altered after serious injury with loss of T helper 1 function and cytokine production and with preservation of T helper 2 function and an increased production of T helper 2… CONTINUE READING

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