The effects of injections of D,L-5-hydroxytryptophan on the efflux of endogenous serotonin and 5-hydroxyindoleacetic acid from a synaptosomal fraction.

@article{Penn1977TheEO,
  title={The effects of injections of D,L-5-hydroxytryptophan on the efflux of endogenous serotonin and 5-hydroxyindoleacetic acid from a synaptosomal fraction.},
  author={Patricia E. Penn and William John Hannan McBride},
  journal={Journal of neurochemistry},
  year={1977},
  volume={28 4},
  pages={
          765-9
        }
}
  • Patricia E. Penn, William John Hannan McBride
  • Published in Journal of neurochemistry 1977
  • Chemistry, Medicine
  • — The effects of i.p. injections of SO mg/kg d,l-5-hydroxytryptophan (5-HTP) and saline alone on the in uitro release of endogenous serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) were studied using preparations of axon terminals (P2 isolated from the telencephalon of rats. The level of 5-HT was 2-fold greater and the level of 5-HIAA was 5-fold greater in the P2 fraction isolated from rats given the d,l-5-HTP injection than from rats given saline injections. At 37°C the in vitro efflux… CONTINUE READING

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