The effects of inhaled fluticasone on airway inflammation in chronic obstructive pulmonary disease: a double-blind, placebo-controlled biopsy study.

@article{Hattotuwa2002TheEO,
  title={The effects of inhaled fluticasone on airway inflammation in chronic obstructive pulmonary disease: a double-blind, placebo-controlled biopsy study.},
  author={Keith L Hattotuwa and Mariusz J Gizycki and Tareq W Ansari and Peter K. Jeffery and Neil C. Barnes},
  journal={American journal of respiratory and critical care medicine},
  year={2002},
  volume={165 12},
  pages={1592-6}
}
Inhaled corticosteroids (ICS) are effective in the treatment of asthma and markedly reduce the numbers of inflammatory cells in bronchial biopsies. However, the effect of ICS on the inflammatory profile of biopsies in smokers with chronic obstructive pulmonary disease (COPD) is unknown. We have performed a double-blind, placebo-controlled, randomized study to compare fluticasone propionate (FP) 500 microg twice daily via a dry powder inhaler and placebo (P) over a 3-month period in subjects… CONTINUE READING