The effects of indomethacin on gastroduodenal morphology and mucosal pH gradient in the healthy human stomach.

@article{Shorrock1990TheEO,
  title={The effects of indomethacin on gastroduodenal morphology and mucosal pH gradient in the healthy human stomach.},
  author={C J Shorrock and Robin J. Prescott and W D Rees},
  journal={Gastroenterology},
  year={1990},
  volume={99 2},
  pages={
          334-9
        }
}
To define further the injury and the mechanisms of mucosal injury induced by indomethacin, the effect of 28-day continuous administration of oral indomethacin on gastroduodenal morphology, gastric histology, and the protective mucus-bicarbonate barrier overlying gastroduodenal mucosa in humans was studied. In the studies, indomethacin caused acute gastroduodenal damage in 100% of cases, with maximal damage at 24 hours of administration. With continued intake this damage resolves, although a… CONTINUE READING

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