The effects of in utero bisphenol A exposure on the ovaries in multiple generations of mice.

@article{Berger2016TheEO,
  title={The effects of in utero bisphenol A exposure on the ovaries in multiple generations of mice.},
  author={Amelia Berger and Ayelet Ziv-Gal and Jonathan Cudiamat and Wei Wang and Changqing Zhou and Jodi Anne Flaws},
  journal={Reproductive toxicology},
  year={2016},
  volume={60},
  pages={39-52}
}
Bisphenol A is used in polycarbonate plastics and epoxy resins. Previous studies show that in utero BPA exposure inhibits germ cell nest breakdown in the F1 generation of mice, but its effects on germ cell nest breakdown and on the ovary in the F2-F3 generations were unknown. Thus, we tested the hypothesis that BPA has transgenerational effects on the ovary. Mice were exposed to BPA in utero (BPA 0.5, 20, or 50μg/kg/day), and ovaries were collected at postnatal days (PND) 4 and 21 from the F1… CONTINUE READING
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