The effects of immunomodulation by macrophage subsets on osteogenesis in vitro

@inproceedings{Loi2016TheEO,
  title={The effects of immunomodulation by macrophage subsets on osteogenesis in vitro},
  author={Florence Loi and Luis Alberto Cordova and Ruth Zhang and Jukka Sakari Pajarinen and Tzu-hua Lin and Stuart B Goodman and Zhenyu Yao},
  booktitle={Stem Cell Research & Therapy},
  year={2016}
}
Bone formation and remodeling are influenced by the inflammatory state of the local microenvironment. In this regard, macrophages are postulated to play a crucial role in modulating osteogenesis. However, the differential effects of macrophage subsets and their plasticity on bone formation are currently unknown. Polarized primary murine macrophages and preosteoblastic MC3T3 cells were co-cultured to investigate the effect of non-activated M0, pro-inflammatory M1, and tissue-regenerative M2… CONTINUE READING
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