The effects of i.v. fentanyl administration on the minimum alveolar concentration of isoflurane in horses.

@article{Thomasy2006TheEO,
  title={The effects of i.v. fentanyl administration on the minimum alveolar concentration of isoflurane in horses.},
  author={Sara M. Thomasy and Eugene P. Steffey and Khursheed R. Mama and Abelardo Solano and Scott D. Stanley},
  journal={British journal of anaesthesia},
  year={2006},
  volume={97 2},
  pages={232-7}
}
BACKGROUND Fentanyl decreases the minimum alveolar concentration (MAC) of inhaled anaesthetics and has been used clinically to reduce the requirements of other anaesthetic drugs in humans and small animals. We hypothesized that i.v. fentanyl would decrease the MAC of isoflurane in horses in a dose-dependent manner. METHODS Following determination of baseline MAC of isoflurane, fentanyl was administered i.v. to target plasma concentrations of 1, 8 and 16 ng ml(-1). Each horse was randomly… CONTINUE READING

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