The effects of hypovolemic hypotension on high-energy phosphate metabolism of traumatized brain in rats.

@article{Ishige1988TheEO,
  title={The effects of hypovolemic hypotension on high-energy phosphate metabolism of traumatized brain in rats.},
  author={Narumi Ishige and Lawrence H. Pitts and Ian Berry and Mitsutoshi Nishimura and Thomas L. James},
  journal={Journal of neurosurgery},
  year={1988},
  volume={68 1},
  pages={129-36}
}
To clarify the effect of hypovolemic hypotension on high-energy phosphate metabolism in head injury, sequential changes in in vivo phosphorus-31 magnetic resonance (31P MR) spectra were compared in 35 rats after impact injury with and without hypotension. Fourteen rats were subjected to hypotension alone (mean arterial blood pressure (MABP) of either 40 or 30 mm Hg for 60 minutes), seven to fluid-percussion impact injury (4 to 5 atm) alone, and 14 to impact injury and hypotension (MABP of 40 to… CONTINUE READING

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