The effects of hyaluronan during the development of osteoarthritis.

  title={The effects of hyaluronan during the development of osteoarthritis.},
  author={Masahiko Yoshioka and Chisato Shimizu and Frederick L Harwood and Richard D. Coutts and David Amiel},
  journal={Osteoarthritis and cartilage},
  volume={5 4},
Ninety-nine mature New Zealand White (NZW) rabbits underwent unilateral anterior cruciate ligament transection (ACLT) and were divided into three groups. The contralateral non-operated knees served as controls. The first group (SA) received intra-articular injections of 0.3 ml hyaluronan (HA: MW; 8 x 10(5)) beginning 4 weeks after ACLT, once a week for 5 weeks. The second group (SV) was injected with vehicle (carrier of HA) in the same fashion as the SA group. The third group (SN) served as a… CONTINUE READING


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