The effects of human proinsulin on glucose turnover and intermediary metabolism.

@article{Davis1991TheEO,
  title={The effects of human proinsulin on glucose turnover and intermediary metabolism.},
  author={Stephen Neil Davis and Peter C Butler and Michael Brown and Sven Beer and W Sobey and I. Hanning and Philip D Home and Charles Nicholas Hales and K. George M. M. Alberti},
  journal={Metabolism: clinical and experimental},
  year={1991},
  volume={40 9},
  pages={953-61}
}
We compared the effects of human proinsulin and human insulin on glucose disposal, suppression of hepatic glucose production (HGP), and intermediary carbohydrate and lipid metabolism. Six young, lean, subjects underwent eight separate euglycemic clamps with low-dose intravenous (IV) infusions of insulin and proinsulin (four each). The insulin infusions gave… CONTINUE READING