The effects of host age on the transport of complement-bound complexes to the spleen and the pathogenesis of intravenous scrapie infection.

@article{Brown2012TheEO,
  title={The effects of host age on the transport of complement-bound complexes to the spleen and the pathogenesis of intravenous scrapie infection.},
  author={Karen Leigh Brown and Anton G. Gossner and Simon Wing Fai Mok and Neil A Mabbott},
  journal={Journal of virology},
  year={2012},
  volume={86 1},
  pages={
          25-35
        }
}
Infections with variant Creutzfeldt-Jakob disease (vCJD) have almost exclusively occurred in young patients, but the reasons for this age distribution are uncertain. Our data suggest that the pathogenesis of many peripherally acquired transmissible spongiform encephalopathy (TSE) agents is less efficient in aged individuals. Four vCJD cases linked to transfusion of vCJD-contaminated blood or blood products have been described. Three cases occurred in elderly patients, implying that intravenous… CONTINUE READING

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