The effects of hormone replacement therapy on hypothalamic neuropeptide gene expression in a primate model of menopause.

@article{Abel1999TheEO,
  title={The effects of hormone replacement therapy on hypothalamic neuropeptide gene expression in a primate model of menopause.},
  author={Ty W Abel and Mary Lou Voytko and Naomi E Rance},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1999},
  volume={84 6},
  pages={2111-8}
}
Menopause is associated with increased neurokinin B (NKB) gene expression and decreased proopiomelanocortin (POMC) gene expression in the human hypothalamus. In the present study, young, ovariectomized cynomolgus monkeys were used in a model of menopause to examine the effects of hormone replacement therapy (HRT) on hypothalamic neuropeptide gene expression. A secondary goal was to determine whether HRT produces signs of estrogen toxicity in the primate hypothalamus by examining POMC neurons… CONTINUE READING