The effects of homocysteine and homocysteic acid on the metabotropic glutamate receptors of cerebellar neurons

Abstract

Incubation of cerebellar neurons with homocysteine or homocysteic acid at a concentration of 500 μM for 30 min increases the intracellular level of free radicals. Specific antagonists of metabotropic glutamate receptors of the groups I (AIDA) and III (MSOP) decreased the accumulation of reactive oxygen species in cells, which suggests that homocysteine and… (More)
DOI: 10.1134/S1819712410020054

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