The effects of high-flow vs low-flow oxygen on exercise in advanced obstructive airways disease.

@article{Chatila2004TheEO,
  title={The effects of high-flow vs low-flow oxygen on exercise in advanced obstructive airways disease.},
  author={Wissam Chatila and Thomas Nugent and Gwendolyn B. Vance and John P Gaughan and Gerard J. Criner},
  journal={Chest},
  year={2004},
  volume={126 4},
  pages={
          1108-15
        }
}
STUDY OBJECTIVES Current options to enhance exercise performance in patients with COPD are limited. This study compared the effects of high flows of humidified oxygen to conventional low-flow oxygen (LFO) delivery at rest and during exercise in patients with COPD. DESIGN Prospective, nonrandomized, nonblinded study. SETTING Outpatient exercise laboratory. PATIENTS Ten patients with COPD, stable with no exacerbation, and advanced airflow obstruction (age, 54 +/- 6 years; FEV(1), 23 +/- 6… 
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References

SHOWING 1-10 OF 21 REFERENCES
Effect of low flow and high flow oxygen delivery on exercise tolerance and sensation of dyspnea. A study comparing the transtracheal catheter and nasal prongs.
TLDR
It is concluded that the use of high-flow oxygen via both transtracheal catheter and NP significantly increased exercise tolerance in COPD patients when compared to low- flow oxygen.
Acute effects of hyperoxia on dyspnea in hypoxemia patients with chronic airway obstruction at rest.
TLDR
Patients with CAO receiving long-term oxygen may benefit from hyperoxic breathing at rest, since it decreases the ventilation and the degree of DH, with concurrent improvement of dyspnea sensation.
Effects of hyperoxia on ventilatory limitation during exercise in advanced chronic obstructive pulmonary disease.
TLDR
Improved exercise endurance during hyperoxia was explained, in part, by a combination of reduced ventilatory demand, improved operational lung volumes, and dyspnea alleviation.
Physiologic benefits of exercise training in rehabilitation of patients with severe chronic obstructive pulmonary disease.
TLDR
Rigorous exercise training for patients with severe COPD yields more efficient exercise breathing pattern and lower V(E); this is associated with improved exercise tolerance.
Ventilatory muscle recruitment in exercise with O2 in obstructed patients with mild hypoxemia.
TLDR
It is concluded that exercise with O2 alters ventilatory muscle recruitment and increases exercise endurance and during exercise inspiring O2, the diaphragm performs more ventilatories work which may prevent overloading the accessory muscles of respiration.
Supplemental oxygen and exercise ability in chronic obstructive airways disease.
TLDR
The influence of supplemental oxygen on exercise performance was assessed in 17 patients with severe airflow obstruction and the benefit from supplemental oxygen was not cancelled by the effort of carrying the portable cylinder.
Airway insufflation. Increasing flow rates progressively reduce dead space in respiratory failure.
TLDR
Airway insufflation exerts its main effects on gas exchange through the reductions in VD that it produces, and the accompanying decreases in VL and/or slight increases in VA seem to stem from the latter.
Function of pulmonary neuronal M(2) muscarinic receptors in stable chronic obstructive pulmonary disease.
TLDR
Pretreatment with the selective M(2) muscarinic receptor agonist pilocarpine prevented the cold air-induced bronchoconstriction, indicating normal function of M( 2) receptors.
Tracheal gas insufflation augments CO2 clearance during mechanical ventilation.
TLDR
Tracheal gas insufflation may eventually prove a useful adjunct to a pressure-targeted strategy of ventilatory management (in either volume-cycled or pressure controlled modes), particularly when the total dead space is heavily influenced by its anatomic component.
Complications of tracheal gas insufflation.
TLDR
This technique cannot be recommended for routine use until commercial systems are available, and extreme care must be exercised if attempts are made to provide TGI.
...
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