The effects of high concentrations of ionic liquid on GB1 protein structure and dynamics probed by high-resolution magic-angle-spinning NMR spectroscopy

@inproceedings{Warner2016TheEO,
  title={The effects of high concentrations of ionic liquid on GB1 protein structure and dynamics probed by high-resolution magic-angle-spinning NMR spectroscopy},
  author={Lisa Rose Warner and Erica L. Gjersing and Shelby E. Follett and Kelly W Elliott and Sergei V Dzyuba and Krisztina Varga},
  booktitle={Biochemistry and biophysics reports},
  year={2016}
}
Ionic liquids have great potential in biological applications and biocatalysis, as some ionic liquids can stabilize proteins and enhance enzyme activity, while others have the opposite effect. However, on the molecular level, probing ionic liquid interactions with proteins, especially in solutions containing high concentration of ionic liquids, has been challenging. In the present work the 13C, 15N-enriched GB1 model protein was used to demonstrate applicability of high-resolution magic-angle… CONTINUE READING
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