The effects of growth hormone and insulin-like growth factor I on the immune system of aged female monkeys.

@article{Leroith1996TheEO,
  title={The effects of growth hormone and insulin-like growth factor I on the immune system of aged female monkeys.},
  author={Derek Leroith and J Yanowski and Eric P. Kaldjian and Elaine S. Jaffe and Tanya Leroith and KU. V. Purdue and Brian A. Cooper and Robert Pyle and Werner Adler},
  journal={Endocrinology},
  year={1996},
  volume={137 3},
  pages={1071-9}
}
The aging process is associated with a significant reduction in circulating GH and insulin-like growth factor I (IGF-I) levels. During this period, immune function also declines. Rodent data suggest that treatment with recombinant human GH (rhGH) or rhIGF-I enhances immune function in normal adult mice. To determine whether rhGH and/or rhIGF-I treatment could improve immune function in aged female rhesus monkeys, we administered rhIGF-I (120 micrograms/kg x day), rhGH (100 micrograms/kg x day… CONTINUE READING