Corpus ID: 21591993

The effects of grayanotoxin I and alpha-dihydrograyanotoxin II on guinea-pig myocardium.

@article{Ku1977TheEO,
  title={The effects of grayanotoxin I and alpha-dihydrograyanotoxin II on guinea-pig myocardium.},
  author={David D. Ku and T. Akera and M. Frank and Theodore M. Brody and J. Iwasa},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1977},
  volume={200 2},
  pages={
          363-72
        }
}
  • David D. Ku, T. Akera, +2 authors J. Iwasa
  • Published 1977
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • We have demonstrated recently that grayanotoxin I (GTX I) produces a positive inotropic effect in isolated guinea-pig atria. In order to determine whether this effect of GTX I is related to the reported action of this compound to increase the sodium permeability of cytoplasmic membranes, the effect of GTX I and alpha-dihydrograyanotoxin II (alpha-2H-GTX II) on electrical and mechanical properties and transmembrane cation movements were studied in guinea-pig myocardium. In electrically driven… CONTINUE READING
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