The effects of graded doses of C-terminal octapeptide of cholecystokinin on small intestinal transit time in man

@article{Levant1974TheEO,
  title={The effects of graded doses of C-terminal octapeptide of cholecystokinin on small intestinal transit time in man},
  author={Jonathan A. Levant and Thomas L. Kun and John Jachna and Richard A. L. Sturdevant and Jon I. Isenberg},
  journal={The American Journal of Digestive Diseases},
  year={1974},
  volume={19},
  pages={207-209}
}
In 6 male subjects without gastrointestinal disease, graded intravenous doses of the C-terminal octapeptide of cholecystokinin (OP-CCK) produced graded decreases in small intestinal transit time. Mean transit time decreased from a control value of 130 minutes after 0.15 M NaCl to 81, 65, and 19 minutes after 5, 10, and 20 ng/kg of OP-CCK. Side effects (nausea and abdominal discomfort) were minimal and transient, lasting less than 3 minutes. Small intestinal radiographic appearance remained… CONTINUE READING

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