The effects of ginsenoside Rb1 on JNK in oxidative injury in cardiomyocytes

@article{Li2012TheEO,
  title={The effects of ginsenoside Rb1 on JNK in oxidative injury in cardiomyocytes},
  author={Jing Li and Z H Shao and Jing-tian Xie and Chong-Zhi Wang and Srinivasan Ramachandran and Jun-jie Yin and Han Htun Aung and Chang-qing Li and Gina Qin and Terry L. Vanden Hoek and Chun-Su Yuan},
  journal={Archives of Pharmacal Research},
  year={2012},
  volume={35},
  pages={1259-1267}
}
Reactive oxygen species (ROS) can induce oxidative injury via iron interactions (i.e. Fenton chemistry and hydroxyl radical formation). Our prior work suggested that American ginseng berry extract and ginsenoside Re were highly cardioprotective against oxidant stress. To extend this study, we evaluated the protective effect of protopanaxadiol-type ginsenoside Rb1 (gRb1) on H2O2-induced oxidative injury in cardiomyocytes and explored the ROS-mediated intracellular signaling mechanism. Cultured… CONTINUE READING
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