The effects of fresh embryo transfers and elective frozen/thawed embryo transfers on pregancy outcomes in poor ovarian responders as defined by the Bologna criteria

@article{elik2015TheEO,
  title={The effects of fresh embryo transfers and elective frozen/thawed embryo transfers on pregancy outcomes in poor ovarian responders as defined by the Bologna criteria},
  author={Serdar Çelik and Niyazi Emre Turgut and Erbil Yağmur and Kubra Boynukalin and Dilek Cengiz Çelik and Necati Findikli and Sevim Purisa and Mustafa Bahçeci},
  journal={Turkish Journal of Obstetrics and Gynecology},
  year={2015},
  volume={12},
  pages={132 - 138}
}
Objective: To compare the effects of fresh embryo transfers (ET) and elective frozen/thawed embryo transfers (eFET) on implantation, clinical pregnancy, and live birth rates in poor ovarian responders, as defined by the Bologna criteria. Materials and Methods: All electronic databases of embryo transfers between January 2011 and January 2014 were retrospectively reviewed. Two hundred fifty-nine of all the fresh ET and 96 of all eFET were included into the study. An antagonist protocol with… 

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The clinical outcomes of fresh versus frozen embryos transfer in women ≥40 years with poor ovarian response
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FET after the freeze-all strategy had no beneficial impact on the clinical outcomes of women ≥40 years with POR and the clinical pregnancy and miscarriage rates, and neonatal characteristics were similar between the 2 groups.
Impact of elective frozen vs. fresh embryo transfer strategies on cumulative live birth: Do deleterious effects still exist in normal & hyper responders?
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TLDR
EFET significantly decreases the risk of moderate and severe OHSS, albeit at the expense of an increased risk of pre-eclampsia, and the effectiveness of eFET in comparison to fresh embryo transfer in different subgroups of patients undergoing IVF/ICSI cycles is evaluated.
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TLDR
Success of IVF treatment can be improved in poor responder by implementing “freeze all” policy, and the proportional comparison among the two groups was found to be statistically significant, showing a higher CPR in the FET group.
Accumulation of embryos over 3 natural modified IVF (ICSI) cycles followed by transfer to improve the outcome of poor responders
TLDR
Accumulation of embryos through 3 NM-IVF cycles before transfer improves livebirth rates and reduces the risk of lacking an embryo for transfer in poor responders aged ≥35 years.
COMPARISON OF A 'FREEZE-ALL' STRATEGY VERSUS A 'FRESH TRANSFER' STRATEGY AMONG POOR RESPONDERS IN ASSISTED REPRODUCTIVE TECHNOLOGY (ART)
TLDR
In poor responder group of patients, IVF outcomes can be improved by implementing freeze all policy, which could be achieved with the help of Pre implantation genetic screening synchronized with latest endometrium receptivity markers.
Freeze-all strategy in IVF/ICSI cycles: an update on clinical utility.
TLDR
It seems justified to implement the freeze-all policy in patients with risk of ovarian hyperstimulation syndrome, hyper-responders and when performing preimplantation genetic testing for aneuploidy in blastocyst stage, but all the other indications, such as implantation failure, high progesterone levels on the trigger day, advanced maternal age, and endometriosis, still lack the evidence to support routine use of the frozen embryo policy.
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