The effects of frataxin silencing in HeLa cells are rescued by the expression of human mitochondrial ferritin.

@article{Zanella2008TheEO,
  title={The effects of frataxin silencing in HeLa cells are rescued by the expression of human mitochondrial ferritin.},
  author={Isabella Zanella and Manuela Derosas and Marcella Corrado and Emiliano Cocco and Patrizia Cavadini and Giorgio Biasiotto and Maura Poli and Rosanna Verardi and Paolo Arosio},
  journal={Biochimica et biophysica acta},
  year={2008},
  volume={1782 2},
  pages={90-8}
}
Frataxin is a ubiquitous mitochondrial iron-binding protein involved in the biosynthesis of Fe/S clusters and heme. Its deficiency causes Friedreich's ataxia, a severe neurodegenerative disease. Mitochondrial ferritin is another major iron-binding protein, abundant in the testis and in sideroblasts from patients with sideroblastic anemia. We previously showed that its expression rescued the defects caused by frataxin deficiency in the yeast. To verify if this occurs also in mammals, we silenced… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 29 extracted citations

Similar Papers

Loading similar papers…