The effects of force inhibition by sodium vanadate on cross-bridge binding, force redevelopment, and Ca2+ activation in cardiac muscle.

@article{Martyn2007TheEO,
  title={The effects of force inhibition by sodium vanadate on cross-bridge binding, force redevelopment, and Ca2+ activation in cardiac muscle.},
  author={Donald A. Martyn and Lucile Schultz Smith and Kareen L. Kreutziger and Sengen Xu and Leepo C. Yu and Michael Regnier},
  journal={Biophysical journal},
  year={2007},
  volume={92 12},
  pages={4379-90}
}
Strongly bound, force-generating myosin cross-bridges play an important role as allosteric activators of cardiac thin filaments. Sodium vanadate (Vi) is a phosphate analog that inhibits force by preventing cross-bridge transition into force-producing states. This study characterizes the mechanical state of cross-bridges with bound Vi as a tool to examine the contribution of cross-bridges to cardiac contractile activation. The K(i) of force inhibition by Vi was approximately 40 microM… CONTINUE READING