The effects of food and dose on the oral systemic availability of itraconazole in healthy subjects

@article{Peer1989TheEO,
  title={The effects of food and dose on the oral systemic availability of itraconazole in healthy subjects},
  author={Achiel van Peer and R. J. H. Woestenborghs and Joseph Heykants and Robert Gasparini and G. Gauwenbergh},
  journal={European Journal of Clinical Pharmacology},
  year={1989},
  volume={36},
  pages={423-426}
}
We have studied the influence of food and dose (50, 100, 200 mg) on the oral systemic availability of the broad spectrum antifungal itraconazole and the pharmacokinetics after repeated dosing of 100 mg in six healthy volunteers. The relative systemic availability of itraconazole capsules compared with solution averaged 39.8% in the fasting state but 102% in… CONTINUE READING