The effects of folate intake on DNA and single-carbon pathway metabolism in the fruit fly Drosophila melanogaster compared to mammals.

@article{Blatch2015TheEO,
  title={The effects of folate intake on DNA and single-carbon pathway metabolism in the fruit fly Drosophila melanogaster compared to mammals.},
  author={Sydella A Blatch and Sally P. Stabler and Jon Fewell Harrison},
  journal={Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology},
  year={2015},
  volume={189},
  pages={34-9}
}
Mechanisms of vitamin function in non-mammals are poorly understood, despite being essential for development. Folate and cobalamin are B-vitamin cofactors with overlapping roles in transferring various single-carbon units. In mammals, one or both is needed for nucleotide synthesis, DNA methylation, amino acid conversions and other reactions. However, there has been little investigation of the response to folate or cobalamin in insects. Here, we manipulated folate intake and potentially… CONTINUE READING