The effects of flutamide on cell-cell junctions in the testis, epididymis, and prostate.

  title={The effects of flutamide on cell-cell junctions in the testis, epididymis, and prostate.},
  author={Anna Hejmej and Barbara Bilińska},
  journal={Reproductive toxicology},
Cell-Cell Interaction-Mediated Signaling in the Testis Induces Reproductive Dysfunction—Lesson from the Toxicant/Pharmaceutical Models
It is illustrated that a potential therapeutic approach can be developed to manage toxicant-induced male reproductive dysfunction through the use of phosphomimetic mutants for overexpression in Sertoli cell epithelium in vitro or in the testis in vivo.
Flutamide treatment reveals a relationship between steroidogenic activity of Leydig cells and ultrastructure of their mitochondria
It is demonstrated that increase in the expression level of steroidogenic proteins in rat testicular tissue as well as elevation of intratesticular sex steroid hormone levels observed in treated animals correspond well to morphological alterations of the Leydig cell ultrastructure.
Flutamide Alters the Expression of Chemerin, Apelin, and Vaspin and Their Respective Receptors in the Testes of Adult Rats
Adipokines influence energy metabolism and have effects on male reproduction, including spermatogenesis and/or Sertoli cell maturation; however, the relationship between these active proteins and
Differential expression of cell-cell junction proteins in the testis, epididymis, and ductus deferens of domestic turkeys (Meleagris gallopavo) with white and yellow semen.
The present study is the first to demonstrate altered levels of junctional protein gene expression in reproductive tissues of male YSS turkeys, suggesting that subtle changes in junctionalprotein expression affect the microenvironment in which spermatozoa develop and mature and thus may have an impact on the appearance of yellow semen in domestic turkeys.
Differential gene expression and hallmarks of stemness in epithelial cells of the developing rat epididymis.
Pathway associations indicated that in epididymides of 7- to 18-day old rats, there was a significant association of regulated genes implicated in stem cells, estrogens, thyroid hormones, and kidney development, while androgen- and estrogen-related pathways were enriched at other phases of development.
Microenvironment for spermatogenesis and sperm maturation.
Three factors, including genetic deletion or abnormalities, aberration of DNA methylation and histone modifications, as well as small RNA dysfunction, and neuroendocrine-immune disorders are involved in functional failure of the male reproductive system are reviewed.
Changes in porcine cauda epididymal fluid proteome by disrupting the HPT axis: Unveiling potential mechanisms of male infertility
Strong evidence is brought of the impact of secondary hypogonadism on the epididymal environment, which is responsible for sperm maturation and storage prior ejaculation, and the differently expressed proteins in the CEF are putative seminal biomarkers for testicular and epidIDymal disorders caused by secondary hypogeal disorders.
Maternal exposure to mixtures of dienestrol, linuron and flutamide. Part I: Feminization effects on male rat offspring.
  • Elga Schreiber, T. García, Mercedes Gómez
  • Medicine, Biology
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2020
Screening of hub genes and evaluation of the growth regulatory role of CD44 in metastatic prostate cancer
The identification of DEGs and the in vivo experimental results helped to elucidate the molecular mechanisms of PCa and provided a potential strategy for the treatment ofPCa.


Androgens and postmeiotic germ cells regulate claudin-11 expression in rat Sertoli cells.
It is shown here that differences between prepubertal and adult testes could be related to dual and opposed regulation of claudin-11 expression resulting from positive control by androgens and an inhibitory effect of postmeiotic germ cells.
Flutamide depresses expression of cortactin in the ectoplasmic specialization between the Sertoli cells and spermatids in the mouse testis.
  • R. Anahara, Y. Toyama, C. Mori
  • Biology
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2006
Androgens regulate the permeability of the blood-testis barrier.
The results suggest that androgen action in Sertoli cells regulates germ cell differentiation, in part by controlling the microenvironment of the seminiferous epithelium, and indicate that hormonal strategies for male contraception may interfere with the blood-testis barrier.
Alterations of Sertoli cell activity in the long-term testicular germ cell death process induced by fetal androgen disruption.
Fetal androgen disruption may induce alterations of Sertoli cell activity probably related to SERToli cell maturation, which potentially leads to increased adult germ cell apoptosis.
Are expression and localization of tight and adherens junction proteins in testes of adult boar affected by foetal and neonatal exposure to flutamide?
Several recent studies have indicated that androgen disruption induced by the administration of anti-androgen flutamide during critical developmental stages results in various reproductive
A role of junction-mediated interactions in cells of the male reproductive tract: impact of prenatal, neonatal, and prepubertal exposure to anti-androgens on adult reproduction.
Recent findings on the tight junction proteins mainly responsible for normal functioning of the barrier within the testis, epididymis and prostate, anchoring junction proteins that play a crucial role in normal cell-cell adhesion, and gap junction proteins through which intercellular communication takes place in the male reproductive tract are presented.
Differential expression of connexin 43 in adult pig testes during normal spermatogenic cycle and after flutamide treatment.
The data suggest that neonatal exposure to flutamide induces long-term effects on the spermatogenic capacity of the pig testis through alterations of Cx43-mediated intercellular communication and permanent alteration of both Sertoli and Leydig cell functions.
Cell junction dynamics in the testis: Sertoli-germ cell interactions and male contraceptive development.
The physiology and biology of junction dynamics in the testis, in particular how these events affect interactions of Sertoli and germ cells in the seminiferous epithelium behind the blood-testis barrier are discussed.