The effects of eticlopride and the selective D3-antagonist PNU 99194-A on food- and cocaine-maintained responding in rhesus monkeys

@article{Claytor2006TheEO,
  title={The effects of eticlopride and the selective D3-antagonist PNU 99194-A on food- and cocaine-maintained responding in rhesus monkeys},
  author={R. Brannon Claytor and Joshua A Lile and Michael A. Nader},
  journal={Pharmacology Biochemistry and Behavior},
  year={2006},
  volume={83},
  pages={456-464}
}
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21 Citations
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Results Citations
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21 Citations

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Citation Type

Differential effects of the dopamine D3 receptor antagonist PG01037 on cocaine and methamphetamine self-administration in rhesus monkeys
Effects of Varenicline on the Reinforcing and Discriminative Stimulus Effects of Cocaine in Rhesus Monkeys
TLDR
The results suggest that varenicline has low abuse liability in monkey models of cocaine abuse, but would not be an effective medication for cocaine addiction.
Reduction of Cocaine Self-Administration and D3 Receptor-Mediated Behavior by Two Novel Dopamine D3 Receptor-Selective Partial Agonists, OS-3-106 and WW-III-55
TLDR
Findings support D3Rs, and possibly D2Rs, as targets for medications aimed at reducing the motivation to seek cocaine.
Dopamine D1 and D3 Receptor Polypharmacology in Cocaine Reward and Cocaine Seeking
TLDR
The aims of this dissertation were to evaluate the effects of the novel strategy of simultaneous treatments with a D3 receptor antagonist and D1 receptor partial agonist in animal models of drug addiction, including cue-induced reinstatement of cocaine seeking, cocaine conditioned place preference (CPP) and cocaine self-administration in rats.
Effects of Acute and Chronic Treatments with Dopamine D2 and D3 Receptor Ligands on Cocaine versus Food Choice in Rats
TLDR
This study compared acute and chronic effects of dopamine D2- and D3-preferring ligands on choice between intravenous cocaine and palatable food in rats and showed distinct profiles, consistent with different pharmacological actions.
Effects of Chronic Buspirone Treatment on Cocaine Self-Administration
TLDR
Findings indicate that buspirone selectively attenuates the reinforcing effects of cocaine in a nonhuman primate model of cocaine self-administration, and has variable effects on cocaine discrimination.
Effects of Oral and Intravenous Administration of Buspirone on Food–Cocaine Choice in Socially Housed Male Cynomolgus Monkeys
TLDR
The data support the utility of drugs targeting D3/D4 receptors as potential treatments for cocaine addiction, particularly in combination with enriching environmental manipulations.
Double Dissociation of the Effects of Haloperidol and the Dopamine D3 Receptor Antagonist ABT-127 on Acquisition vs. Expression of Cocaine-Conditioned Activity in Rats
TLDR
It is hypothesized that haloperidol and ABT-127 will produce a doubly dissociable effect on acquisition versus expression of cocaine-conditioned activity and results suggest that D2 receptors are more critically involved in acquisition than initial expression and D3 receptor-selective doses are more critical in expression than acquisition of conditioned activity based on cocaine.
Dopaminergic mechanism of reward-related incentive learning: Focus on the dopamine d3 receptor
TLDR
Results suggest that Drd3 plays a more important role in the expression than in the acquisition of a CPP or conditioned motor activity, and similar effects may be seen for responding for cues based on drugs or nutritional rewards.
Chapter 46 – The Role of Dopamine D3 Receptors in Cocaine-Related Behavior
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References

SHOWING 1-10 OF 37 REFERENCES
The effects of benzamide analogues on cocaine self-administration in rhesus monkeys
TLDR
Cocaine-maintained responding varied as a function of dose and was characterized as an inverted U-shaped function, while cocaine intake increased in a dose-related fashion, while D3 receptor antagonists are more likely to selectively decrease intake relative to response rates than D2 receptor antagonists.
Antagonism of cocaine self‐administration by selective dopamine D1 and D2 antagonists
TLDR
The results show that self-administration of cocaine can be comparably modified by drugs that selectively block dopamine D1 or D2 receptors, and a 3 to 6-fold increase in dose was necessary to restore optimal performances.
Effects of dopamine D-1 and D-2 antagonists on cocaine self-administration under different schedules of reinforcement in the rat.
  • S. B. Caine, G. Koob
  • Psychology, Biology
    The Journal of pharmacology and experimental therapeutics
  • 1994
TLDR
It is suggested that benzazepine dopamine D-1 antagonists, at low doses, may attenuate the reinforcing properties of cocaine more selectively than other dopamine receptor antagonists.
Self-administration of the dopamine D3 agonist 7-OH-DPAT in rhesus monkeys is modified by prior cocaine exposure
TLDR
Results suggest that despite comparable reinforcing effects in cocaine-substitution studies, 7-OH-DPAT and cocaine differ in their rate of acquisition, perhaps indicating a lower abuse liability for 7- OH-DPat.
The effects of a D1 and a D2 dopamine antagonist on behavior maintained by cocaine or food
Effects of dopamine indirect agonists and selective D1-like and D2-like agonists and antagonists on cocaine self-administration and food maintained responding in rats
Cocaine- and food-maintained responding under a multiple schedule in rhesus monkeys: environmental context and the effects of a dopamine antagonist
TLDR
Cocaine self-administration under a multiple schedule with food reinforcement is influenced by the environmental context and changes in the magnitude of food reinforcement would affect cocaine-maintained response rates and influence the behavioral potency of a dopamine antagonist to decrease cocaine self- administration.
Effects of phentermine on responding maintained under multiple fixed-ratio schedules of food and cocaine presentation in the rhesus monkey.
TLDR
Results show that phentermine is effective in decreasing cocaine self-administration and suggest that it may be an effective medication for cocaine abuse.
Attenuation of Cue-Controlled Cocaine-Seeking by a Selective D3 Dopamine Receptor Antagonist SB-277011-A
TLDR
The results suggest that D3 dopamine receptors may be critically involved in cue-controlled drug-seeking behavior independently of any interaction with the reinforcing effects of cocaine itself, and may therefore provide a therapeutic target in the treatment of relapse to cocaine use induced by CSs.
Effects of dopamine D(1-like) and D(2-like) agonists in rats that self-administer cocaine.
TLDR
D(2) receptor-related neuronal mechanisms may be especially important in mediating the abuse-related effects of cocaine and have prominent reinforcing effects and enhance the effects of self- Administered cocaine in rats with extensive cocaine self-administration experience.
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