The effects of eticlopride and the selective D3-antagonist PNU 99194-A on food- and cocaine-maintained responding in rhesus monkeys

@article{Claytor2006TheEO,
  title={The effects of eticlopride and the selective D3-antagonist PNU 99194-A on food- and cocaine-maintained responding in rhesus monkeys},
  author={R. Brannon Claytor and Joshua A Lile and Michael A. Nader},
  journal={Pharmacology Biochemistry and Behavior},
  year={2006},
  volume={83},
  pages={456-464}
}
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Effects of Acute and Chronic Treatments with Dopamine D2 and D3 Receptor Ligands on Cocaine versus Food Choice in Rats
TLDR
This study compared acute and chronic effects of dopamine D2- and D3-preferring ligands on choice between intravenous cocaine and palatable food in rats and showed distinct profiles, consistent with different pharmacological actions.
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TLDR
Findings indicate that buspirone selectively attenuates the reinforcing effects of cocaine in a nonhuman primate model of cocaine self-administration, and has variable effects on cocaine discrimination.
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TLDR
The data support the utility of drugs targeting D3/D4 receptors as potential treatments for cocaine addiction, particularly in combination with enriching environmental manipulations.
Double Dissociation of the Effects of Haloperidol and the Dopamine D3 Receptor Antagonist ABT-127 on Acquisition vs. Expression of Cocaine-Conditioned Activity in Rats
TLDR
It is hypothesized that haloperidol and ABT-127 will produce a doubly dissociable effect on acquisition versus expression of cocaine-conditioned activity and results suggest that D2 receptors are more critically involved in acquisition than initial expression and D3 receptor-selective doses are more critical in expression than acquisition of conditioned activity based on cocaine.
Dopaminergic mechanism of reward-related incentive learning: Focus on the dopamine d3 receptor
TLDR
Results suggest that Drd3 plays a more important role in the expression than in the acquisition of a CPP or conditioned motor activity, and similar effects may be seen for responding for cues based on drugs or nutritional rewards.
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