The effects of eticlopride and the selective D3-antagonist PNU 99194-A on food- and cocaine-maintained responding in rhesus monkeys.

@article{Claytor2006TheEO,
  title={The effects of eticlopride and the selective D3-antagonist PNU 99194-A on food- and cocaine-maintained responding in rhesus monkeys.},
  author={Renee Claytor and Joshua A. Lile and Michael A. Nader},
  journal={Pharmacology, biochemistry, and behavior},
  year={2006},
  volume={83 3},
  pages={
          456-64
        }
}
The dopamine D3 receptor is mainly expressed in regions of the brain associated with the limbic system. D3 receptor blockade may antagonize cocaine reinforcement while producing less severe extrapyramidal side effects than blockade of D2 receptors. The purpose of the present studies was to evaluate the effects of a selective D3 receptor antagonist and a non-selective D2/D3 receptor antagonist on food- and cocaine-maintained responding under two schedules of cocaine self-administration. Adult… CONTINUE READING

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