The effects of endotoxaemia on protein metabolism in skeletal muscle and liver of fed and fasted rats.

@article{Jepson1986TheEO,
  title={The effects of endotoxaemia on protein metabolism in skeletal muscle and liver of fed and fasted rats.},
  author={M M Jepson and Jennifer M. Pell and Peter C. Bates and Douglas Millward},
  journal={The Biochemical journal},
  year={1986},
  volume={235 2},
  pages={329-36}
}
The response of muscle and liver protein metabolism to either a single or three successive daily injections of an endotoxin (Escherichia coli lipopolysaccharide, serotype 0127 B8; 1 mg/ml, 0.3 mg/100 g body wt.) was studied in vivo in the fed rat, and at 24 and 30 h after endotoxin treatment during fasting. In the fed rats there was a catabolic response in muscle, owing to a 60-100% increase in muscle protein degradation rate, and a 52% fall in the synthesis rate. Although there was a 20… CONTINUE READING