The effects of endothelin-1 on degranulation, cytokine, and growth factor production by skin-derived mast cells.

@article{Matsushima2004TheEO,
  title={The effects of endothelin-1 on degranulation, cytokine, and growth factor production by skin-derived mast cells.},
  author={Hironori Matsushima and Nobuo Yamada and Hiroyuki Matsue and Shinji Shimada},
  journal={European journal of immunology},
  year={2004},
  volume={34 7},
  pages={1910-9}
}
Endothelin-1 (ET-1), originally described as a vasoconstrictor, is now known to be involved in pathogenesis of various disorders including vascular, inflammatory, and fibrotic diseases. Recent studies suggest that mast cells are also involved in the same pathological conditions. In this study, we tested a hypothesis that ET-1 would affect mast cell functions and contribute to such disease conditions, using fetal skin-derived cultured mast cells (FSMC) and bone marrow-derived cultured mast cells… CONTINUE READING

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