The effects of dose and timing of esomeprazole administration on 24-h, daytime and night-time acid inhibition in healthy volunteers.

@article{WilderSmith2010TheEO,
  title={The effects of dose and timing of esomeprazole administration on 24-h, daytime and night-time acid inhibition in healthy volunteers.},
  author={Clive H Wilder-Smith and Kerstin R{\"o}hss and S Bokelund Singh and M. Bidva Sagar and P{\'e}ter Nagy},
  journal={Alimentary pharmacology & therapeutics},
  year={2010},
  volume={32 10},
  pages={1249-56}
}
BACKGROUND Symptoms of gastro-oesophageal reflux disease (GERD) may persist despite daily treatment with a proton pump inhibitor (PPI). AIM To compare the pharmacodynamic effect of various esomeprazole dosage and timing regimens in healthy volunteers. METHODS The effect of different esomeprazole dosage regimens [20 mg once daily (od) before breakfast or dinner; 20 mg twice daily (b.d.); 40 mg od before breakfast, dinner or at bedtime; and 40 mg b.d.] on 24-h, daytime and night-time acid… CONTINUE READING

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