The effects of dopamine-depleting brain lesions on the electrophysiological activity of rat substantia nigra dopamine neurons

@article{Hollerman1990TheEO,
  title={The effects of dopamine-depleting brain lesions on the electrophysiological activity of rat substantia nigra dopamine neurons},
  author={Jeffrey R. Hollerman and Anthony A. Grace},
  journal={Brain Research},
  year={1990},
  volume={533},
  pages={203-212}
}
Extensive damage to the nigrostriatal dopamine (DA) system initiates a number of compensatory changes that may be involved in counterbalancing the effects of the lesion. In this study, we examined whether changes in the electrophysiological activity of the remaining DA cells play a role in compensating for 6-hydroxydopamine (6-OHDA)-induced depletions of striatal DA. DA cell activity in lesioned rats was assessed along three dimensions: (1) the relative proportion of the remaining DA neurons… CONTINUE READING
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