The effects of dopamine D3 agonists and antagonists in a nonhuman primate model of tardive dyskinesia

@article{Malik2004TheEO,
  title={The effects of dopamine D3 agonists and antagonists in a nonhuman primate model of tardive dyskinesia},
  author={Peter Malik and Maibritt B. Andersen and Linda Peacock},
  journal={Pharmacology Biochemistry and Behavior},
  year={2004},
  volume={78},
  pages={805-810}
}
Upregulation of dopamine D3, not D2, receptors correlates with tardive dyskinesia in a primate model
TLDR
It is suggested for the first time that upregulated striatal D3 receptors correlate with TD in nonhuman primates, adding new insights to the dopamine receptor supersensitivity hypothesis.
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TLDR
The study clearly shows that the African-Carribean population differs from the Caucasian population with regard to the association of TD with the polymorphisms studied and suggests that the association is the result of a changed susceptibility of the patients, independent of the action of the antipsychotics on these receptors.
Evaluation of the efficacy of pramipexole for treating levodopa-induced dyskinesia in patients with Parkinson's disease.
TLDR
Pramipexole may be a therapeutic option for treating LID because its effects on D3 dopamine receptors may balance the D1 dopamine receptor supersensitivity associated with LID.
A late appearance by the dopamine D‐3 receptor
  • P. Jenner
  • Psychology, Biology
    Movement disorders : official journal of the Movement Disorder Society
  • 2014
TLDR
The D-3 dopamine receptor was first cloned in 1990 and was shown to be present largely in limbic regions of the brain, with much lower levels expressed in striatal areas, which suggests that despite opposing actions on postsynaptic striatal dopamine receptors, dopamine agonist and antagonist compounds might induce common changes linked to dyskinesia induction.
Pramipexole reduces parkinsonian tremor induced by pilocarpine infusion in the rat striatum
Identification and Characterization of a Novel Class of Atypical Dopamine Receptor Agonists
TLDR
A novel class of atypical dopamine receptor agonists that include three structurally dissimilar compounds that will help determine the physiological and pathophysiological relevance of D3 receptor tolerance and SRT properties are discovered.
Animal models of tardive dyskinesia.
Medication-Induced Tardive Dyskinesia: A Review and Update.
TLDR
The reported incidence of TD seems to be reduced with the use of atypical antipsychotic drugs, yet the risk of developing TD remains with these medications, and the need for a prevention-based focus of TD treatment is highlighted.
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