The effects of different ventilatory settings on pulmonary and systemic inflammatory responses during major surgery.

@article{Wrigge2004TheEO,
  title={The effects of different ventilatory settings on pulmonary and systemic inflammatory responses during major surgery.},
  author={Hermann Wrigge and Ulrike Uhlig and Joerg Zinserling and Elisabeth Behrends-Callsen and Gunther Ottersbach and Matthias Konstantin Fischer and Stefan Uhlig and Christian Putensen},
  journal={Anesthesia and analgesia},
  year={2004},
  volume={98 3},
  pages={775-81, table of contents}
}
UNLABELLED Mechanical ventilation with high tidal volumes (V(T)) and zero or low positive end-expiratory pressure increased mediator release to inflammatory stimuli or acute lung injury. We studied whether mechanical ventilation modifies the inflammatory responses during major thoracic or abdominal surgery. Sixty-four patients undergoing elective thoracotomy (n = 34) or laparotomy (n = 30) were randomized to receive either mechanical ventilation with V(T) = 12 or 15 mL/kg ideal body weight… CONTINUE READING