The effects of dietary methionine restriction on the function and metabolic reprogramming in the liver and brain – implications for longevity

  title={The effects of dietary methionine restriction on the function and metabolic reprogramming in the liver and brain – implications for longevity},
  author={Du{\vs}an Mladenovi{\'c} and Tatjana Radosavljevi{\'c} and Dragan Hrn{\vc}i{\'c} and Aleksandra Ra{\vs}i{\'c}-Markovi{\'c} and Olivera Stanojlovi{\'c}},
  journal={Reviews in the Neurosciences},
  pages={581 - 593}
Abstract Methionine is an essential sulphur-containing amino acid involved in protein synthesis, regulation of protein function and methylation reactions. Dietary methionine restriction (0.12–0.17% methionine in food) extends the life span of various animal species and delays the onset of aging-associated diseases and cancers. In the liver, methionine restriction attenuates steatosis and delays the development of non-alcoholic steatohepatitis due to antioxidative action and metabolic… 

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