The effects of diet and lifestyle interventions on insulin resistance in patients with nonalcoholic fatty liver disease: a systematic review

@article{Paris2017TheEO,
  title={The effects of diet and lifestyle interventions on insulin resistance in patients with nonalcoholic fatty liver disease: a systematic review},
  author={Tonya Paris and Elena S. George and Stuart K. Roberts and Audrey C. Tierney},
  journal={European Journal of Gastroenterology \& Hepatology},
  year={2017},
  volume={29},
  pages={867–878}
}
Nonalcoholic fatty liver disease (NAFLD) results from excessive fat accumulation in the liver in the absence of excessive alcohol consumption. Insulin resistance (IR) is proposed to be an underlying pathogenic factor in the development and progression of disease. There are currently no proven pharmacotherapies and weight loss is the only prescribed treatment despite a lack of evidence to support a specific diet or lifestyle therapy. The aim of this review is to evaluate the efficacy of dietary… 
View on Wolters Kluwer
natap.org
8 Citations
Background Citations
2

8 Citations

What Is the Optimal Dietary Composition for NAFLD?

Changing focus from single nutrient to dietary patterns may offer greater translation capability to research findings, and investment in whole food dietary education approaches to engage lifelong health behaviours targeted at culturally appropriate healthy food and lifestyle choices are needed.

Obesity and nonalcoholic fatty liver disease: From pathophysiology to therapeutics.

Association of Weight Loss Interventions With Changes in Biomarkers of Nonalcoholic Fatty Liver Disease

Evidence appeared to support changing the current clinical guidelines and recommending formal weight loss programs to treat people with nonalcoholic fatty liver disease.

Efficacy of the holistic, psychonutritional approach of Centro DAI e Obesità di Città della Pieve in the management of type 2 diabetes among patients with obesity and dysfunctional eating

Investigating the effectiveness of the psycho-nutritional treatment of “Centro DAI e Obesità” of Città della Pieve on weight loss and glucose management in dysfunctional eaters with obesity and type 2 diabetes found PNT is effective in improving T2DM management in patients with Obesity and dysfunctional eating.

Emerging Role of Hepatic Ketogenesis in Fatty Liver Disease

Current evidence suggests that ketogenesis dispose up to two-thirds of the lipids entering the liver, and its dysregulation significantly contribute to the NAFLD pathogenesis, and ketone body administration in mice and humans shows a significant improvement inNAFLD.

Role of mitochondrial depolarization and disrupted mitochondrial homeostasis in non-alcoholic steatohepatitis and fibrosis in mice.

It is shown that hepatic mtDepo occurs early in mice fed a Western diet, followed by increased mitophagic burden, suppressed mitochondrial biogenesis and dynamics, and mitochondrial depletion.

Impaired Adipogenesis and Dysfunctional Adipose Tissue in Human Hypertrophic Obesity.

The subcutaneous adipose tissue (SAT) is the largest and best storage site for excess lipids. However, it has a limited ability to expand by recruiting and/or differentiating available precursor…

Simultaneous co-assembly of fenofibrate and ketoprofen peptide for the dual-targeted treatment of nonalcoholic fatty liver disease (NAFLD).

We have developed a co-assembled nanosystem based on fenofibrate and ketoprofen by tactfully utilizing their simultaneous benzophenone interaction, which greatly enhances the bioavailability of…

References

SHOWING 1-10 OF 66 REFERENCES

Lifestyle interventions for the treatment of non-alcoholic fatty liver disease in adults: a systematic review.

A randomised controlled trial of a Mediterranean Dietary Intervention for Adults with Non Alcoholic Fatty Liver Disease (MEDINA): study protocol

This trial aims to demonstrate in a large cohort of participants with NALFD that a Mediterranean diet independent of weight loss can result in significant benefits in liver fat and insulin sensitivity and that these changes are sustained at 12 months.

Diet Macronutrients Composition in Nonalcoholic Fatty Liver Disease: A Review on the Related Documents

Although a hypocaloric diet could prevent the progression of fat accumulation in liver, the diet composition is another aspect which should be considered in diet therapy of patients with NAFLD.

Clinical trial: a nutritional supplement Viusid, in combination with diet and exercise, in patients with nonalcoholic fatty liver disease

The results indicate that treatment with diet and exercise leads to a notable improvement in the histological features of NAFLD; however, the administration of Viusid intensifies the improvements of histological findings, especially of steatosis and inflammation.

Diet prescription for non‐alcoholic fatty liver disease: Is it worth the effort? A systematic review

There is good evidence that clinically significant weight reduction can improve steatosis and risk factors for non-alcoholic fatty liver disease and a relationship may exist between the frequency of dietetic consultations and amount of weight reduction achieved in patients with non- Alcoholic fatty Liver disease.

The Mediterranean diet improves hepatic steatosis and insulin sensitivity in individuals with non-alcoholic fatty liver disease.

Metformin versus dietary treatment in nonalcoholic hepatic steatosis: a randomized study

In this 6-month prospective study, both low-dose metformin and dietary treatment alone ameliorated liver steatosis and metabolic derangements in patients with NAFLD.

Review: The role of insulin resistance in nonalcoholic fatty liver disease.

Treatments aimed at reducing insulin resistance have had some success, but larger placebo-controlled studies are needed to fully establish the efficacy of these interventions and possibly others in reducing the deleterious effects of fat accumulation in the liver.

The role of diet and nutrient composition in nonalcoholic Fatty liver disease.

Weight reduction improves markers of hepatic function and insulin resistance in type-2 diabetic patients with non-alcoholic fatty liver.

About 15 % reduction in BMI is effective to improve the liver condition and insulin resistance in type-2 diabetics with NAFLD.
...