The effects of dexamethasone and dehydroepiandrosterone (DHEA) on cytokines and receptor expression in a human osteoblastic cell line: potential steroid-sparing role for DHEA.

@article{Harding2006TheEO,
  title={The effects of dexamethasone and dehydroepiandrosterone (DHEA) on cytokines and receptor expression in a human osteoblastic cell line: potential steroid-sparing role for DHEA.},
  author={Greg Harding and Ying Tat Mak and Bronwen Alice James Evans and Judy Y.S. Cheung and Douglas Macdonald and Geeta N Hampson},
  journal={Cytokine},
  year={2006},
  volume={36 1-2},
  pages={
          57-68
        }
}
Osteoporosis and associated fractures are the most common and debilitating complication of glucocorticoid use. The use of alternative anti-inflammatory agents without the deleterious skeletal effects of glucocorticoids is needed. Dehydroepiandrosterone (DHEA) may have immunomodulatory as well as positive effects on bone. For our further understanding of the mechanisms of action of DHEA, as a steroid-sparing agent, we investigated and compared the effects of dexamethasone (DEX) and DHEA on the… CONTINUE READING
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