The effects of density on the topological structure of the mitochondrial DNA from trypanosomes.

@article{Diao2012TheEO,
  title={The effects of density on the topological structure of the mitochondrial DNA from trypanosomes.},
  author={Yuanan Diao and Kyle Hinson and Ray Kaplan and Mariel V{\'a}zquez and Javier Arsuaga},
  journal={Journal of mathematical biology},
  year={2012},
  volume={64 6},
  pages={1087-108}
}
Trypanosomatida parasites, such as trypanosoma and lishmania, are the cause of deadly diseases in many third world countries. A distinctive feature of these organisms is the three dimensional organization of their mitochondrial DNA into maxi and minicircles. In some of these organisms minicircles are confined into a small disk volume and are topologically linked, forming a gigantic linked network. The origins of such a network as well as of its topological properties are mostly unknown. In this… CONTINUE READING