The effects of denervation, reinnervation, and muscle imbalance on functional muscle length and elbow flexion contracture following neonatal brachial plexus injury.

@article{Weekley2012TheEO,
  title={The effects of denervation, reinnervation, and muscle imbalance on functional muscle length and elbow flexion contracture following neonatal brachial plexus injury.},
  author={Holly Weekley and Sia Nikolaou and Liangjun Hu and Emily A. Eismann and Christopher Wylie and Roger Cornwall},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  year={2012},
  volume={30 8},
  pages={1335-42}
}
The pathophysiology of paradoxical elbow flexion contractures following neonatal brachial plexus injury (NBPI) is incompletely understood. The current study tests the hypothesis that this contracture occurs by denervation-induced impairment of elbow flexor muscle growth. Unilateral forelimb paralysis was created in mice in four neonatal (5-day-old) BPI groups (C5-6 excision, C5-6 neurotomy, C5-6 neurotomy/repair, and C5-T1 global excision), one non-neonatal BPI group (28-day-old C5-6 excision… CONTINUE READING

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