The effects of dark rearing on the development of the visual cortex of the rat

@article{Borges1978TheEO,
  title={The effects of dark rearing on the development of the visual cortex of the rat},
  author={S Borges and Martin Berry},
  journal={Journal of Comparative Neurology},
  year={1978},
  volume={180}
}
  • S. Borges, M. Berry
  • Published 15 July 1978
  • Biology, Medicine
  • Journal of Comparative Neurology
The effects of dark rearing on the development of the visual cortex has been studied in Wistar rats, as have the effects of subsequent light exposure on recovery. Five groups of animals were used: (1) light exposed until 30‐40 days post partum (dpp) (2) dark reared until 30‐40 dpp (3) dark reared until 80‐120 dpp (4) dark reared to 21 dpp, then light exposed until 40 dpp (5) light exposed to 21 dpp and then dark reared until 40 dpp. Golgi‐Cox impregnations of layer IV stellate cell dendritic… 
The quantitative effects of dark-rearing and light exposure on the laminar composition and depth distribution of neurons and glia in the visual cortex (area 17) of the rat
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Results indicate specific alterations in the glial cell composition of the rat visual cortex following periods of dark-rearing and light-exposure, and changes in the density of glial cells in layer 5 may reflect functional modifications in neurons projecting to the superior colliculus.
Quantitative morphological effects of dark-rearing and light exposure on the synaptic connectivity of layer 4 in the rat visual cortex (area 17)
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Evidence is provided indicating marked structural alterations in the synaptic connectivity of layer 4 of the rat visual cortex following the light exposure of rats dark-reared upto weaning and visual deprivation severely affected the ‘inhibitory’ circuitry in the major thalamorecipient territory of the visual cortex.
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The role of pattern vision in the increase of visual cortex acetylcholinesterase after first exposure of dark reared rats to light
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Visual cortex is rescued from the effects of dark rearing by overexpression of BDNF
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In dark-reared transgenic mice, visual acuity, receptive field size of visual cortical neurons, critical period for ocular dominance plasticity, and intracortical inhibition were indistinguishable from those observed in light- reared mice, suggesting that BDNF overexpression is sufficient for the development of aspects of visual cortex in the absence of visual experience.
Effects of dark-rearing on the vascularization of the developmental rat visual cortex
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The results suggest that the absence of visual stimuli retards the maturation of the visual cortex including its vascular bed, and also show that cortex thickness and vessel density are significantly lower in dark-reared rats.
Dark-rearing fails to affect the basal dendritic fields of layer 3 pyramidal cells in the kitten's visual cortex.
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Although stripe-rearing can specifically alter the orientation of the dendritic fields of the layer 3 pyramidal cells, and dark-reared has been shown by others to alter the size of layer 4 stellate cells, dark- rearing failed to affect the dendedritic field orientations.
Effects of dark-rearing on the vascularization of the developmental rat visual cortex
TLDR
The results suggest that the absence of visual stimuli retards the maturation of the visuaf cortex including its vascular bed, and also show that cortex thickness and vessel density are significantly lower in dark-reared rats.
Postnatal development of neuropeptide Y-containing neurons in the visual cortex of normal- and dark-reared rats
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The results suggest that the normal decline in NPY neurons is not entirely mediated by visual experience since it takes place, albeit to a modified extent, in its total absence.
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