The effects of d-cycloserine, a partial agonist at the glycine binding site, on spatial learning and working memory in scopolamine-treated rats.

@article{Pitknen1995TheEO,
  title={The effects of d-cycloserine, a partial agonist at the glycine binding site, on spatial learning and working memory in scopolamine-treated rats.},
  author={Mikko T Pitk{\"a}nen and Jouni Sirvi{\"o} and E. Macdonald and T Ekonsalo and Paavo Riekkinen},
  journal={Journal of neural transmission. Parkinson's disease and dementia section},
  year={1995},
  volume={9 2-3},
  pages={133-44}
}
The present study investigated the effect of d-cycloserine, a partial agonist at the glycine binding site on NMDA receptor complex, on the performance of scopolamine-treated adult rats in a water maze task assessing spatial learning and in a delayed non-matching to position task assessing working memory in a spatial context. In the spatial learning task, scopolamine (0.4 mg/kg, i.p.) impaired acquisition (increased escape latency and distance) and increased swimming speed of rats. D-cycloserine… CONTINUE READING
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