The effects of cytochalasins on actin polymerization and actin ATPase provide insights into the mechanism of polymerization.

@article{Brenner1980TheEO,
  title={The effects of cytochalasins on actin polymerization and actin ATPase provide insights into the mechanism of polymerization.},
  author={Stephen L. Brenner and Edward D. Korn},
  journal={The Journal of biological chemistry},
  year={1980},
  volume={255 3},
  pages={841-4}
}
Substoichiometric concentrations of cytochalasin D inhibited the rate of polymerization of actin in 0.5 mM MgCl2, increased its critical concentration and lowered its steady state viscosity. Stoichiometric concentrations of cytochalasin D in 0.5 mM MgCl2 and even substoichiometric concentrations of cytochalasin D in 30 mM KCl, however, accelerated the rate of actin polymerization, although still lowering the final steady state viscosity. Cytochalasin B, at all concentrations in 0.5 mM MgCl2 or… CONTINUE READING

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