The effects of cyanide on brain mitochondrial cytochrome oxidase and respiratory activities.

@article{Pettersen1993TheEO,
  title={The effects of cyanide on brain mitochondrial cytochrome oxidase and respiratory activities.},
  author={John C. Pettersen and Steven D. Cohen},
  journal={Journal of applied toxicology : JAT},
  year={1993},
  volume={13 1},
  pages={
          9-14
        }
}
Brain mitochondrial cytochrome oxidase and respiratory activities were compared after in vivo and in vitro exposure to cyanide. For the in vivo studies, mice were exposed to a non-lethal (4 mg kg-1) or lethal (20 mg kg-1) dose of KCN. From these mice, purified brain mitochondria were prepared and cytochrome oxidase and respiratory activities measured. Results of these experiments revealed greater inhibition of cytochrome oxidase activity following a lethal (20 mg kg-1) than a non-lethal (4 mg… CONTINUE READING

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