The effects of copper ions on glutamate receptors in cultured rat cortical neurons.

@article{Weiser1996TheEO,
  title={The effects of copper ions on glutamate receptors in cultured rat cortical neurons.},
  author={Thomas Weiser and Marion Wienrich},
  journal={Brain research},
  year={1996},
  volume={742 1-2},
  pages={211-8}
}
Copper plays an important role in the function of many physiological processes and can affect different neurotransmitter systems. In this study, we used the patch-clamp technique to investigate the effect of copper ions on glutamate receptors in cultured rat cortical neurons. Cu2+ inhibited (S)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate receptors with an IC50 of 4.3 +/- 0.6 microM (with 100 microM kainate, holding potential -60 mV). The concentration-response could… CONTINUE READING