The effects of co-administration of selenium and cis-platin (CDDP) on CDDP-induced toxicity and antitumour activity.

@article{Ohkawa1988TheEO,
  title={The effects of co-administration of selenium and cis-platin (CDDP) on CDDP-induced toxicity and antitumour activity.},
  author={Kiyoshi Ohkawa and Yutaka Tsukada and H. Dohzono and Kazuhiko Koike and Yoshiteru Terashima},
  journal={British Journal of Cancer},
  year={1988},
  volume={58},
  pages={38 - 41}
}
The therapeutic antitumour activity and host toxicity of cis-platin (CDDP), which was administered with selenium (sodium selenite) was studied on the growth of a human yolk sac tumour grown in nude mice. Treatment consisted of CDDP single agent chemotherapy (3 weeks) or preliminary PVB combination chemotherapy (CDDP + vinblastine + bleomycin, 2 weeks). Selenium was co-administered from day 1 to 5 with each therapeutic regimen. The administration of CDDP alone caused significant reduction in… CONTINUE READING