The effects of cisapride on plasma L-dopa levels and clinical response in Parkinson's disease.

@article{Neira1995TheEO,
  title={The effects of cisapride on plasma L-dopa levels and clinical response in Parkinson's disease.},
  author={W D Neira and Victor Omar Castellanos S{\'a}nchez and Mar{\'i}a {\'A}ngeles Mena and Justo Garc{\'i}a de Y{\'e}benes},
  journal={Movement disorders : official journal of the Movement Disorder Society},
  year={1995},
  volume={10 1},
  pages={66-70}
}
Cisapride (CIS) is a prokinetic agent that increases gastrointestinal motility in normal individuals and improves constipation in Parkinson's disease (PD). We studied the effects of CIS on the clinical response and the peripheral pharmacokinetics of orally administered L-dopa given to patients with PD. Twenty patients with idiopathic PD and chronic constipation, whose response to L-dopa was suboptimal or characterized by fluctuations, agreed to participate in an open study that lasted for 2… CONTINUE READING

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