The effects of chronic lithium on the EEG and locomotor response to drug challenge in rats.


Adult male Wistar rats were given lithium as a dietary supplement or a control diet for a period of eight weeks. Spectral analysis of cortical EEG activity revealed a significant shift in the amplitude and variance of the theta rhythm in rats administered lithium. A significant increase in the locomotor response to morphine over time but not to saline or… (More)


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