The effects of chromatin organization on variation in mutation rates in the genome

@article{Makova2015TheEO,
  title={The effects of chromatin organization on variation in mutation rates in the genome},
  author={Kateryna D. Makova and Ross C. Hardison},
  journal={Nature Reviews Genetics},
  year={2015},
  volume={16},
  pages={213-223}
}
The variation in local rates of mutations can affect both the evolution of genes and their function in normal and cancer cells. Deciphering the molecular determinants of this variation will be aided by the elucidation of distinct types of mutations, as they differ in regional preferences and in associations with genomic features. Chromatin organization contributes to regional variation in mutation rates, but its contribution differs among mutation types. In both germline and somatic mutations… CONTINUE READING
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