The effects of central administration of physostigmine in two models of anxiety

  title={The effects of central administration of physostigmine in two models of anxiety},
  author={Helena Sienkiewicz-Jarosz and Piotr Maciejak and Pawel Krza̧ścik and Agnieszka I. Członkowska and Janusz Szyndler and Andrzej Bidziński and Wojciech Kostowski and Adam Płażnik},
  journal={Pharmacology Biochemistry and Behavior},

Fluoxetine-induced anxiety and nervousness.

A new animal model is described to study the central action of antidepressants reflecting dysphoric-like effects observed in the initial phase of the treatment with fluoxetine, and the central mechanism of the reported effects might involve stimulation of 5-HT2C receptors by fluoxettine in animals with PTZ-induced decrease in the threshold for emotional arousal.

Anxiolytic effects of an acetylcholinesterase inhibitor, physostigmine, in the adult zebrafish

The results suggest that the level of anxiety in zebrafish can be reduced by activating acetylcholinergic neurotransmitter systems, which is mediated in part by muscarinic receptors.

Cycloheximide impairs acquisition but not extinction of cocaine self-administration

Roles of p75NTR, Long-Term Depression, and Cholinergic Transmission in Anxiety and Acute Stress Coping



The effects of physostigmine and cholinergic receptor ligands on novelty-induced neophobia

It was found that in a limited dose-range physostigmine and nicotine given peripherally or ICV selectively disinhibited rat exploration in the open field, whereas scopolamine stimulated animal motor activity and increased thigmotaxis, and AChE-I can selectively affect brain emotional processes evoked by neophobia-related stimuli.

The role of 5‐HT1A receptors in mediating the anxiogenic effects of nicotine following lateral septal administration

Investigation of the role of the 5‐HT1A receptors in the lateral septum in the mediation of the anxiogenic effects of nicotine in the social interaction and elevated plus maze tests of anxiety in the rat indicates that these effects are mediated at least in part by these 5‐ HT1A receptor receptors.

Hippocampal and septal injections of nicotine and 8-OH-DPAT distinguish among different animal tests of anxiety

Thigmotaxis as a test for anxiolytic activity in rats