The effects of cell density and metabolite flux on cellular dynamics.

@article{Othmer1978TheEO,
  title={The effects of cell density and metabolite flux on cellular dynamics.},
  author={Hans G. Othmer and John Aldridge},
  journal={Journal of mathematical biology},
  year={1978},
  volume={5 2},
  pages={169-200}
}
Density-dependent regulation of cell growth in tissue culture is a well-known phenomenon but the mechanism of regulation remains obscure. Here we explore the effects of cell density and metabolite flux on the collective dynamics of a cell population. The intracellular dynamics are modelled by positive feedback kinetic mechanisms of the kind known to apply to yeast cells. Several experimental observations related to glycolytic oscillations are predicted and it is suggested that the general… CONTINUE READING