The effects of catalase gene overexpression on life span and resistance to oxidative stress in transgenic Drosophila melanogaster.

@article{Orr1992TheEO,
  title={The effects of catalase gene overexpression on life span and resistance to oxidative stress in transgenic Drosophila melanogaster.},
  author={William C. Orr and Rajindar S. Sohal},
  journal={Archives of biochemistry and biophysics},
  year={1992},
  volume={297 1},
  pages={35-41}
}
Oxygen free radicals and hydroperoxides have been postulated to play a causal role in the aging process, implying that antioxidant enzymes may act as longevity determinants. Catalase (H2O2:H2O2 oxidoreductase; EC1.11.1.6) is the sole enzyme involved in the elimination of H2O2 in Drosophila melanogaster; glutathione peroxidase being absent. A genomic fragment containing the Drosophila catalase gene was used to construct transgenic Drosophila lines by means of P element-mediated transformation… CONTINUE READING
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